Schindler

class synergy.higher.Schindler(single_drug_models=None)

Schindler’s multidimensional Hill equation model.

E_reference(d)

Return the expected effect of the combination of drugs at doses d1 and d2.

Parameters:

d (ArrayLike) – doses (shape=(N,) or (M, N) where N is the number of drugs and M is the number of samples)

Return ArrayLike:

Reference (additive) values of E at the given doses

fit(d, E, **kwargs)

Fit the model to data.

Parameters:

• d (array_like) – Array of doses measured

• E (array_like) – Array of effects measured at doses d

• kwargs – Optional parameters to pass to scipy.optimize.curve_fit().

Returns:

ArrayLike

Return type:

The synergy of the drug combination at doses d

property is_fit

True if the model has been fit to data.

property is_specified

True if all single drug models are specified